The Dallas Cowboys (2-2-1) and Carolina Panthers (2-3) head into Week 6’s matchup with a ton of momentum. Here are the odds, predictions, and free expert picks for Cowboys vs. Panthers.
Cowboys vs. Panthers: Game Information
shoutout 4⃣ pic.twitter.com/nwyDCsAQqE
— Dallas Cowboys (@dallascowboys) October 6, 2025
Game: Cowboys vs. Panthers
Date: Oct. 12
Time: 1 p.m. ET
Location: Bank of America Stadium — Charlotte, North Carolina
TV Channel: FOX
Live Stream: FOX One, NFL+
Cowboys vs. Panthers Odds and Predictions
Coming up clutch pic.twitter.com/G8fVAwVGdg
— Carolina Panthers (@Panthers) October 7, 2025
Maybe Jerry Jones knew something about Brian Schottenheimer that the rest of the public didn’t believe.
Schottenheimer and the Cowboys offense are rolling after a dominant 37-22 victory over the New York Jets. The Cowboys put up 416 yards of total offense, including 180 on the ground.
The Cowboys rank first in yards per game (406.6), third in passing yards per game (272.2), fourth in points per game (30.2), and eighth in rushing yards per game (134.4).
Dak Prescott is arguably having the second-best season for quarterbacks behind Baker Mayfield. Prescott has thrown for 1,356 yards, 10 touchdowns, and three interceptions, with a QBR of 76.5.
Prescott is doing most of this without CeeDee Lamb, who has been out since injuring his foot in Week 3.
Speaking of offense, the Carolina Panthers overcame a 17-point deficit to defeat the Miami Dolphins 27-24.
Panthers running back Rico Dowdle, who played for the Cowboys in 2024, exploded for 206 yards against the Dolphins.
Carolina is a different team at home — 2-0 in Carolina and 0-3 on the road.
However, Prescott is excellent against teams under. 500 — 33-18-2 ATS and 40-13 SU. Even if Lamb and the trio of offensive linemen don’t play, I still like Dallas to outscore Carolina in the victory.
Pick: Cowboys -3.5 (+100)
Cowboys vs. Panthers Prop
As previously mentioned, Prescott is playing at an elite level, especially as a passer.
Prescott has at least two passing touchdowns in three of five games, with seven over the past two weeks.
Carolina’s secondary has played solidly all season, ranking 10th against the pass (204.4 yards per game).
Carolina has faced Trevor Lawrence, Kyler Murray, Michael Penix, Drake Maye, and Tua Tagovailoa. None of those quarterbacks is better than Prescott, who should have success through the air in Week 6.
Pick: Dak Prescott Over 1.5 Passing Touchdowns (-115)
*Odds as of Oct. 7. Lines are subject to change. Please verify with your sportsbook before placing bets.
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