The Carolina Panthers woke up Monday morning in first place. It proved to be a short stint as co-leaders of the NFC South as Christian McCaffrey led the host San Francisco 49ers to a 20-9 victory on Monday Night Football.
McCaffrey collected 142 yards from scrimmage and a touchdown against his former team. His 31 touches marked the 11th time in his career that he mustered at least 30 touches in a game.
The Panthers’ inconsistency flared up again. One week after quarterback Bryce Young threw for a franchise-record 448 yards, he went 18-for-29 for 169 yards, one touchdown pass and two interceptions at Levi’s Stadium.
Young led the Panthers to just three first-half points despite the defense recording three interceptions, two by Jaycee Horn, before being sidelined in the second half with a concussion, and one by Mike Jackson.
With the Tampa Bay Buccaneers (6-5) dropping their third straight Sunday night, the Panthers (6-6) chartered a cross-country, overnight plane trip back to Charlotte, N.C., in second place.
X (Twitter) fans reacted to the 49ers improving to 8-4 and solidifying the injury-plagued squad as NFL playoff contenders …
GOT IT DONE
pic.twitter.com/pyw1n9fhVU
— San Francisco 49ers (@49ers) November 25, 2025
The Panthers’ defense experienced a steady dose of McCaffrey on the first drive. The ex-Panthers running back who leads the league in first downs this season, touched the ball nine times on the opening drive, compiling 40 yards from scrimmage …
Christian McCaffrey’s first drive:
6 carries for 28 rushing yards
3 catches for 12 receiving yardsFeeding CMC early
pic.twitter.com/HKpQsugakB
— Underdog (@Underdog) November 25, 2025
Panthers DL Tershawn Wharton hustled to get off the field, avoiding an early 12 men-on-the-field penalty …
Look at the diving effort from Tershawn Wharton to get off the field
CARvsSF on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/pRgG57g1UH— NFL (@NFL) November 25, 2025
49ers quarterback Brock Purdy hit Jauan Jennings for a 12-yard touchdown pass, capping a season-best 15-play, 72-yrd scoring drive. Jennings caught a short pass over the middle and broke the tackles of three players (Nick Scott, Jaycee Horn and Krys Barnes) …
Jauan Jennings bounces off defenders to cap a 15-play 49ers opening drive
CARvsSF on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/dPHFqb2bfp— NFL (@NFL) November 25, 2025
Big mistake. Following cornerback Jaycee Horn’s interception on the first play of the 49ers’ second drive, Young threw an interception in the end zone when he had an opening to run it into the end zone …
Bryce Young could’ve walked this into the end zone
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— DraftKings (@DraftKings) November 25, 2025
Two plays after Panthers safety Tre’von Moehrig failed to jump on a loose fumble, Horn intercepted his second pass of the first half. Purdy’s third pick led the Panthers’ Ryan Fitzgerald kicking a field goal, cutting the 49ers’ lead to 7-3 …
JAYCEE HORN AGAIN! 3RD PANTHERS INT.
CARvsSF on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/uDwhX4pu24— NFL (@NFL) November 25, 2025
Horn suffered a concussion at some point in the first half. Symptoms started developing at halftime and he was held out of the action. Corey Thornton also suffered a lower-body injury, propelling Chau Smith-Wade into a big role. He finished with four tackles, including taking McCaffrey down for a loss …
Jaycee Horn (concussion) will not return. Big loss. He was the Panthers’ best player tonight.
— Joe Person (@josephperson) November 25, 2025
One play after Thornton went down, McCaffrey went wide and benefited from solid downfield blocking to give the 49ers a 17-3 advantage with 4:42 left in the third quarter …
CMC with beautiful blocking ahead for a TD against his former team!
CARvsSF on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/hKrOeso21z— NFL (@NFL) November 25, 2025
The Panthers finally generated a big play, cutting their deficit to 17-9 after a failed 2-point conversion …
Bryce Young connects with McMillan for 6
Panthers creeping back in this one
(via @NFL)pic.twitter.com/7MRugWKZco
— Yahoo Sports (@YahooSports) November 25, 2025
After the 49ers converted a field goal, Young attempted to bring the Panthers back to within one score with 6:27 remaining, but the 49ers’ Ji’Ayir Brown executed his second interception on Monday Night Football. The officials missed a clear hold by Renardo Green intended target Tetairoa McMillan …
Ji’Ayir Brown intercepts Bryce Young for the 2nd time tonight!
CARvsSF on ESPN/ABC
Stream on @NFLPlus and ESPN App pic.twitter.com/pDxeZF8btf— NFL (@NFL) November 25, 2025
A low blow by Moehrig sparked a post-game altercation with Jennings …
Panthers Safety Tre’von Moehrig hit Jauan Jennings with a low blow during the game, then Jennings got into with him after the game
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— ⟁⟁⟁ (@fsh733) November 25, 2025
Final score: 49ers 20, Panthers 9 …
Cat’s out the bag
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— San Francisco 49ers (@49ers) November 25, 2025
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